Question
Antibody-drug conjugates ("ADCs") are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. They are like a precision guided "biological missile" with the ability to destroy the cancer cells accurately, improving the therapeutic window and reducing the off-targeted side effects.
a) Please draw a schematic to illustrate the major components of an ADC drug and their functions. (5 marks)
b) Please list out THREE different types of therapeutic monoclonal antibodies used for ADCs and comment on their level of immunogenicity. (4 marks)
c) Please describe the mechanisms of action of an ADC drug. (4 marks)
d) Please comment on how the side effects of an ADC drug arise. (2 marks)