c) Rationale

What is the rationale to use such a combination of drugs? (2 marks)

The standard combinatĀ­ion of the RIPE regimen has arisen due to:

  • their diverse mechanisms of action
  • their complementary activities
  • Combined this way reduce the risk of resistance and the duration of treatment 

The most important point to make is that a combination of antibiotics is required to prevent resistance developing to the few antibiotics which are effective against MTB.

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