Ann Lee, aged 38, has moderate persistent asthma and uses a combination of two drugs in a single inhaler as daily maintenance and reliever therapy to reduce exacerbation frequency. Unfortunately, she experienced waking with asthma symptoms three to four times a week and had increased asthma symptoms during her daily walk to work and workouts about three months ago. Upon her visit to your respiratory speciality clinic, she completed a 5-day course of oral prednisone from her family doctor a month ago without significant improvement in her asthma symptoms. Therefore, you offer her to get a subcutaneous injection of benralizumab as add-on therapy because she has a high number of blood eosinophils. 

(a) What are the TWO classes of drugs with given drug names in the inhaler? (3 marks) 

(b) State the mechanism of action for each class of drugs. What is the rationale for such a combination of two drugs? (7 marks) 

(c) What is prednisone? Why does the family doctor decide to give her oral prednisone? (2 marks) 

(d) State the THREE major side (adverse) effects of the two classes of drugs. (3 marks) 

(e) Which class of drug does benralizumab belong to? State its mechanism of action and TWO major side effects. (5 marks)